Synthesis, Characterisation and Biological Evaluation of Nalidixic Acid Metal Complexes

JASEM Front Page
Metalcomplexes of Nalidixic acid such as [Cu(NDX)2].2H2O, [Zn(NDX)2].2H2O, [Ni(NDX)2].6H2O, and [Fe(NDX)2(H2O)Cl].5H2O have been synthesized and characterised by elemental analysis, IR ,UV-Visibe, ESR, NMR,XRD spectrscopic techniques. The results of elemental analysis show that two molecules of the tioconazoledrug are attached per metal ion. Thermal analysis was studied by TGA, DSC method. Morphological studies were carried out by scanning electron microscopic method. Furthur the complexes were screened for their antimicrobial property. The results of elemental analysis show that two molecules of thetioconazole drug are attached per metal ion. From the spectral studies a square planar geometry was proposed for the copper complex. Tetrahedral geometry for zinc and nickel complex and octahedral geometry for iron complex.In conclusion, prepared complexes showed enhanced biological activities than the parent drug that might be of interest for future research.

Keywords:Antimicrobial , geometry, ligand, metal complexes, nalidixic acid.


  1. A. Albert, ThePhysico-Chemical Basis of Therapy: SelectiveToxicity, (6thed., Chapman & Hall, London, 1979).
  2. M.N. Hughes ,The Inorganic Chemistry of Biological Processes, 2nded., Wiley, New York, (1981).
  3. J. Liu, E.B. Wang, J.Peng, Y.S. Zhou, Rare Earths (17, 1999, 139)
  4. S. Chakrabarti, D. Dasgupta D. Bhattacharyya, Journal of Biological Physics,26, (2000) 203
  5. A.R. Shaikh, R. Giridhar, M.R. Yadav, International Journal of Pharmaceutics, 332 (2007) 24-30.
  6. D.E King., R. Malone, S.H. Lilley, American .Family. Physician,61(2000) 2741–2748
  7. V.T. Andriole, The Quinolones, (3rd Ed, Academic Press, San Diego2000).
  8. J. Kljun, A.K. Bytzek, W. Kandioller, C. Bartel, M.A. Jakupec, C.G. Hartinger, B.K. Kepplerand I. Turel, Organometallics, 30,2011, 2506.
  9. A.H. Al-Kubais, K.Z. Ismail, Synthesis, Spectroscopic Characterization, and Biological Activities of Transition Metal Complexes Derived from a Tridentate Schiff Base, Canadian Journal of Chemistry, 1994, 72(8), 1785-1788.
  10. A.B.P Lever ., Inorganic Spectroscopy,(1984, second ed. Elsevier Pub, New York).
  11. Ballhausen C.J., An Introduction to Ligand Field Theory, 1962.
  12. H. Chowdhury, J. Banerjee H.Rahaman, D. Bose B.K. Ghosh, Synthesis, characterisation and redox behaviour of mixed ligand complexes of osmium(II/III/IV)-phosphines, Indian Journal of Chemistry, 2004, 43A(5), 2112-2118.
  13. R.RayG.B.Kaufiman,EPR Spectra and covalency of bis(amidinourea/O-alkyl-1-amidinourea)copper(II) complexes Part II. Properties of the CuN4-2− chromophoreInorganicaChemicaActa , 1990, 173(2), 207-214.
  14. C.Chow,R.D. Willett, ESR spectrum and the theory of zero field splitting for the exchange coupled Cu2Cl62− dimers in ϕ4AsCuCl3, Journal of chemical physics,1973, 59(11), 5903-5915.
  15. A.M.Benial, V.Ramakrishnan,R.Murugesen, Single crystal EPR of Cu(C5H5NO)6(BF4)2:an example of admixed ground state, Spectrochimica.Acta 2000, 56(14), 2775-2781.
  16. G.B. Deacon, A.D. Phillips, Relationships between the carbon-oxygen stretching frequencies of carboxylato complexes and the type of carboxylate coordination. Coordination Chemistry Reviews, 1980, 33(3), 227–250.
  17. M.G. El-WahedM.S.Refat S.M. El-Megharbel , Synthesis, spectroscopic and thermal characterization of some transition metal complexes of folic acid. SpectrochimicaActa , 2008,70(4), 911–916.
  18. R. Olar R, M.Badea D.Marinescu, LCalu ,C.Bucur Thermal behaviour of some new complexes with bismacrocyclic ligands as potential biological active species. Journal of Thermal Analysis and Calorimetry, 2011, 105(2), 571–575.
  19. Henderson D.K.,Managing methicillin-resistant staphylococci: A paradigm for preventing nosocomial transmission of resistant organisms, American Journal of Medicine, 2006, 119(6),45-52.
  20. Bauer A.W., Kirby W., Sherries J.C., Truck M., Antibiotic susceptibility testing by a standardized singledisk method, American Journal of Clinical Pathology. 1996, 45, 493-496.
  21. Anjaneyula Y., Rao R.P., Preparation, characterization and antimicrobial activity studies on some ternary complexes of Cu (II) with acetylacetone and various salicylic acids. Synthesis and Reactivity in Inorganic Metal–Organic Chemistry, 1986,16,257-272.